Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Impact of Environmental Factors on Monogenic Mendelian Diseases.

Toxicological sciences : an official journal of the Society of Toxicology - 27 Apr 2021

Tukker Anke M, Royal Charmaine D, Bowman Aaron B, McAllister Kimberly A

Abstract excerpt

Environmental factors and gene-environment interactions modify the variable expressivity, progression, severity, and onset of some classic (monogenic) Mendelian-inherited genetic diseases. Cystic fibrosis, Huntington disease, Parkinson's disease, and sickle cell disease are examples of well-known Mendelian disorders that are influenced by exogenous exposures. Environmental factors may act by direct or indirect...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Gene-Environment Interaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetics and Neurodevelopmental Disorders

Share to Hemoglobinopathies and Related Disorders

Share to Mutation

Share to Parkinson Disease

Share to Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 33677604
DOI: 10.1093/toxsci/kfab022
PMCID: PMC8599782

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Impact of Environmental Factors on Monogenic Mendelian Diseases.PMID 33677604Read ↗

Genetically transitional disease: a new concept in genomic medicine.Semantic proximity Read ↗

Gene-environment interactions and their impact on human health.Semantic proximity Read ↗

Strategies for dissecting genetic-environmental interactions in neurodegenerative disorders.Semantic proximity Read ↗

Gene-environment interactions and the complexity of human genetic diseases.Semantic proximity Read ↗

The "etiome": identification and clustering of human disease etiological factors.Semantic proximity Read ↗

Genetics meets environment: evaluating gene-environment interactions in neurologic diseases.Semantic proximity Read ↗

Gene-environment interactions in the development of complex disease phenotypes.Semantic proximity Read ↗

Genetic Discoveries Highlight Environmental Factors as Key Drivers of Liver Disease.Semantic proximity Read ↗

Environmentally induced epigenetic transgenerational inheritance of disease susceptibility.Semantic proximity Read ↗

The Environmental Genome Project: phase I and beyond.Semantic proximity Read ↗

Lessons from studying monogenic disease for common disease.Semantic proximity Read ↗

Environmental genomics: a key to understanding biology, pathophysiology and disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.