Article
Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway.
Nature cell biology - 1 Oct 2006
Denoyelle Christophe, Abou-Rjaily George, Bezrookove Vladimir, Verhaegen Monique, Johnson Timothy M, Fullen Douglas R, Pointer Jenny N, Gruber Stephen B, Su Lyndon D, Nikiforov Mikhail A, Kaufman Randal J, Bastian Boris C, Soengas Maria S
Abstract excerpt
Dysfunction of the endoplasmic reticulum (ER) has been reported in a variety of human pathologies, including cancer. However, the contribution of the ER to the early stages of normal cell transformation is largely unknown. Using primary human melanocytes and biopsies of human naevi (moles), we show that the extent of ER stress induced by cellular oncogenes may define the mechanism of activation of premature...
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