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Rat bone marrow progenitor cells transduced in situ by rSV40 vectors differentiate into multiple central nervous system cell lineages.

Stem cells (Dayton, Ohio) - 1 Dec 2006

Louboutin Jean-Pierre, Liu Bianling, Reyes Beverly A S, Van Bockstaele Elisabeth J, Strayer David S

Abstract excerpt

Using bone marrow-directed gene transfer, we tested whether bone marrow-derived cells may function as progenitors of central nervous system (CNS) cells in adult animals. SV40-derived gene delivery vectors were injected directly into femoral bone marrow, and we examined transgene expression in blood and brain for 0-16 months thereafter by immunostaining for FLAG epitope marker. An average of 5% of peripheral blood...

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PMID: 16960137
DOI: 10.1634/stemcells.2006-0124

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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