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Article

Genotyping hepatitis C viruses from Southeast Asia by a novel line probe assay that simultaneously detects core and 5' untranslated regions.

Journal of clinical microbiology - 1 Nov 2006

Noppornpanth Suwanna, Sablon Erwin, De Nys Kathy, Truong Xuan Lien, Brouwer Jan, Van Brussel Marianne, Smits Saskia L, Poovorawan Yong, Osterhaus Albert D M E, Haagmans Bart L

Abstract excerpt

Hepatitis C viruses (HCVs) display a high level of sequence diversity and are currently divided into six genotypes. A line probe assay (LiPA), which targets the 5' untranslated region (5'UTR) of the HCV genome, is widely used for genotyping. However, this assay cannot distinguish many genotype 6 subtypes from genotype 1 due to high sequence similarity in the 5'UTR. We investigated the accuracy of a new generation...

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Identifiers

PMID: 16957039
DOI: 10.1128/JCM.01122-06
PMCID: PMC1698374

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