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Realistic Rodents? Debate Grows Over New Mouse Models of Cancer

5 Sept 2006

Abstract excerpt

In laboratories and conference rooms across the vast U.S. cancer research enterprise, scientists are conducting a high-stakes debate over which mouse models of cancer should be used to screen new drugs before they enter human trials. Change is needed. Thirty years of experience with subcutaneous xenografts, human tumors implanted under the skin of the mouse, have satisfied few because so many drugs that cure...

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PMID: 16954466
DOI: 10.1093/jnci/djj381

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