Article
Microarray comparative genomic hybridization reveals genome-wide patterns of DNA gains and losses in post-Chernobyl thyroid cancer.
Radiation research - 1 Sept 2006
Kimmel Robert R, Zhao Lue Ping, Nguyen Doan, Lee Somnit, Aronszajn Mark, Cheng Chun, Troshin Vladislav P, Abrosimov Alexander, Delrow Jeffrey, Tuttle R Michael, Tsyb Anatoli F, Kopecky Kenneth J, Davis Scott, Neiman Paul E
Abstract excerpt
Genetic gains and losses resulting from DNA strand breakage by ionizing radiation have been demonstrated in vitro and suspected in radiation-associated thyroid cancer. We hypothesized that copy number deviations might be more prevalent, and/or occur in genomic patterns, in tumors associated with presumptive DNA strand breakage from radiation exposure than in their spontaneous counterparts. We used cDNA...
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