Article
Isolation and characterization of temperature-sensitive and thermostable mutants of the human receptor-like protein tyrosine phosphatase LAR.
The Journal of biological chemistry - 5 Jun 1991
Tsai A Y, Itoh M, Streuli M, Thai T, Saito H
Abstract excerpt
Human LAR is a transmembrane receptor-like protein whose cytoplasmic region contains two tandemly duplicated domains homologous to protein tyrosine phosphatases (PTPases). Whereas the membrane-proximal domain I has enzymatic activity, the membrane-distal domain II has no apparent catalytic activity but seems to have a regulatory function. In order to study structure-function relationships of the LAR PTPase, LAR...
Topics
- Amino Acid Sequence
- Base Sequence
- Electrophoresis, Polyacrylamide Gel
- Escherichia coli
- Gene Expression Regulation, Bacterial
- Gene Expression Regulation, Enzymologic
- Hot Temperature
- Humans
- Hydroxylamine
- Hydroxylamines