Article
Prophylaxis of irinotecan-induced diarrhea with neomycin and potential role for UGT1A1*28 genotype screening: a double-blind, randomized, placebo-controlled study.
The oncologist - 1 Sept 2006
de Jong Floris A, Kehrer Diederik F S, Mathijssen Ron H J, Creemers Geert-Jan, de Bruijn Peter, van Schaik Ron H N, Planting André S Th, van der Gaast Ate, Eskens Ferry A L M, Janssen Jos Th P, Ruit Jan B, Verweij Jaap, Sparreboom Alex, de Jonge Maja J A
Abstract excerpt
OBJECTIVE: Delayed-type diarrhea is a common side effect of irinotecan and is associated with a bacterial-mediated formation of the active irinotecan metabolite SN-38 from its glucuronide conjugate in the intestine. Based on a pilot study, we hypothesized that concomitant administration of the antibiotic neomycin would diminish exposure of the gut to SN-38 and ameliorate the incidence and severity of diarrhea....
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