Article
Expressed in the yeast Saccharomyces cerevisiae, human ERK5 is a client of the Hsp90 chaperone that complements loss of the Slt2p (Mpk1p) cell integrity stress-activated protein kinase.
Eukaryotic cell - 1 Nov 2006
Truman Andrew W, Millson Stefan H, Nuttall James M, King Victoria, Mollapour Mehdi, Prodromou Chrisostomos, Pearl Laurence H, Piper Peter W
Abstract excerpt
ERK5 is a mitogen-activated protein (MAP) kinase regulated in human cells by diverse mitogens and stresses but also suspected of mediating the effects of a number of oncogenes. Its expression in the slt2Delta Saccharomyces cerevisiae mutant rescued several of the phenotypes caused by the lack of...
Topics
- Animals
- Gene Expression Regulation
- Genetic Complementation Test
- HSP90 Heat-Shock Proteins
- Humans
- MADS Domain Proteins
- MAP Kinase Kinase 1
- Mice
- Mitogen-Activated Protein Kinase 7
- Mitogen-Activated Protein Kinases
- Molecular Chaperones
- Mutation
- Phenotype