Article
Expressed in the yeast Saccharomyces cerevisiae, human ERK5 is a client of the Hsp90 chaperone that complements loss of the Slt2p (Mpk1p) cell integrity stress-activated protein kinase.
Eukaryotic cell - 1 Nov 2006
Truman Andrew W, Millson Stefan H, Nuttall James M, King Victoria, Mollapour Mehdi, Prodromou Chrisostomos, Pearl Laurence H, Piper Peter W
Abstract excerpt
ERK5 is a mitogen-activated protein (MAP) kinase regulated in human cells by diverse mitogens and stresses but also suspected of mediating the effects of a number of oncogenes. Its expression in the slt2Delta Saccharomyces cerevisiae mutant rescued several of the phenotypes caused by the lack of Slt2p (Mpk1p) cell integrity MAP kinase. ERK5 is able to provide this cell integrity MAP kinase function in yeast, as...
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