Article
Association between PON 1 polymorphisms, PON activity and diabetes complications.
Journal of diabetes and its complications - 1 Jan 2000
Hofer Sabine E, Bennetts Bruce, Chan Albert K, Holloway Bethwyn, Karschimkus Connie, Jenkins Alicia J, Silink Martin, Donaghue Kim C
Abstract excerpt
The paraoxonase (PON) gene cluster maps to human chromosome 7q21-22. In the PON 1 gene, several polymorphisms in the promoter and coding regions have been identified and are known to influence gene expression levels. Promoter polymorphisms have been shown to have the strongest influence on paraoxonase activity levels. Paraoxonase, a high-density lipoprotein associated enzyme, protects lipoproteins from oxidation....
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