Article
T-cell-independent and T-cell-dependent B-cell responses to exposed variant surface glycoprotein epitopes in trypanosome-infected mice.
Infection and immunity - 1 Jul 1990
Reinitz D M, Mansfield J M
Abstract excerpt
The T-cell dependency of B-cell responses to variant surface glycoprotein (VSG) epitopes exposed in their native surface conformation on Trypanosoma brucei rhodesiense clone LouTat 1 was investigated. T-cell requirements were examined by analyses of gamma globulin preparations derived from trypanosome-infected BALB/c nude (nu/nu) and thymus-intact (nu/+) mice. A radioimmunoassay was used to selectively quantitate...
Topics
- Animals
- Antibodies, Protozoan
- Antigens, Protozoan
- Antigens, T-Independent
- B-Lymphocytes
- Epitopes
- Formaldehyde
- Genetic Variation
- Immunization
- Kinetics
- Mice