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Article

Investigation of the Lith1 candidate genes ABCB11 and LXRA in human gallstone disease.

Hepatology (Baltimore, Md.) - 1 Sept 2006

Schafmayer Clemens, Tepel Jürgen, Franke Andre, Buch Stephan, Lieb Sören, Seeger Marcus, Lammert Frank, Kremer Bernd, Fölsch Ulrich R, Fändrich Fred, Schreiber Stefan, Hampe Jochen

Abstract excerpt

Genetic susceptibility in the causation of gallbladder diseases was recognized as early as 1937. A major gallstone susceptibility locus (Lith1) was identified in 1995 by quantitative trait locus mapping in mice. Two attractive positional and functional candidate genes in LXRA and ABCB11 are located in this interval. ABCB11 is associated with progressive familial cholestasis. This study was undertaken to...

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PMID: 16941683
DOI: 10.1002/hep.21289

Genes

ABCB11

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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