RovA, a global regulator of Yersinia pestis, specifically required for bubonic plague.

doi:10.1073/pnas.0603456103

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Article

RovA, a global regulator of Yersinia pestis, specifically required for bubonic plague.

Proceedings of the National Academy of Sciences of the United States of America - 5 Sept 2006

Cathelyn Jason S, Crosby Seth D, Lathem Wyndham W, Goldman William E, Miller Virginia L

Abstract excerpt

The pathogenic species of Yersinia contain the transcriptional regulator RovA. In Yersinia pseudotuberculosis and Yersinia enterocolitica, RovA regulates expression of the invasion factor invasin (inv), which mediates translocation across the intestinal epithelium. A Y. enterocolitica rovA mutant has a significant decrease in virulence by LD(50) analysis and an altered rate of dissemination compared with either...

Topics

Animals
Bacterial Proteins
Disease Models, Animal
Female
Gene Expression Regulation, Bacterial
Mice
Mice, Inbred C57BL
Mutation
Plague
Promoter Regions, Genetic
Regulon
Transcription Factors
Virulence
Yersinia pestis

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Identifiers

PMID: 16938880
DOI: 10.1073/pnas.0603456103
PMCID: PMC1569194

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