Article
Common coding variant in the TCF7L2 gene and study of the association with type 2 diabetes in Japanese subjects.
Journal of human genetics - 1 Jan 2008
Kunika Kiyoshi, Tanahashi Toshihito, Numata Shusuke, Ueno Shu-Ichi, Ohmori Tetsuro, Nakamura Naoto, Tsugawa Kazue, Miyawaki Katsuyuki, Moritani Maki, Inoue Hiroshi, Itakura Mitsuo
Abstract excerpt
Genetic variants of the transcription factor 7-like 2 (TCF7L2) gene affect the risk of type 2 diabetes in populations with multiple ethnic groups. However, a comprehensive survey of this gene has not been done for a Japanese population. Thus, we conducted this gene-based association study, in which the common genetic variants were analyzed. Using 24 Japanese type 2 diabetic subjects, we first screened a 9.5 kb...
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