Article
The C677T polymorphism in the methylenetetrahydrofolate reductase gene (MTHFR), maternal use of folic acid supplements, and risk of isolated clubfoot: A case-parent-triad analysis.
American journal of epidemiology - 1 Nov 2006
Sharp Linda, Miedzybrodzka Zosia, Cardy Amanda H, Inglis Julie, Madrigal Londale, Barker Simon, Chesney David, Clark Caroline, Maffulli Nicola
Abstract excerpt
Worldwide, 1-4 per 1,000 births are affected by clubfoot. Clubfoot etiology is unclear, but both genetic and environmental factors are thought to be involved. Low folate status in pregnant women has been implicated in several congenital malformations, and folate metabolism may be affected by polymorphisms in the methylenetetrahydrofolate reductase gene (MTHFR). Using a case-parent-triad design, the authors...
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