Article
CagA protein secreted by the intact type IV secretion system leads to gastric epithelial inflammation in the Mongolian gerbil model.
The Journal of pathology - 1 Nov 2006
Shibata W, Hirata Y, Maeda S, Ogura K, Ohmae T, Yanai A, Mitsuno Y, Yamaji Y, Okamoto M, Yoshida H, Kawabe T, Omata M
Abstract excerpt
Helicobacter pylori causes various gastro-duodenal diseases, including gastric cancer. The CagA protein, an H. pylori virulence factor, induces morphological changes in host cells and may be associated with the development of peptic ulcer and gastric carcinoma. The present study has analysed the...
Topics
- Animals
- Antigens, Bacterial
- Apoptosis
- Bacterial Proteins
- Cell Division
- Cytokines
- Disease Models, Animal
- Epithelial Cells
- Gastric Mucosa
- Gastritis
- Gene Expression
- Gerbillinae
- Helicobacter Infections
- Helicobacter pylori