Article
The Evaluation of Putative Virulence Factors ofHelicobacter pylorifor Gastroduodenal Disease by Use of a Short‐Term Mongolian Gerbil Infection Model
1 Feb 2002
Abstract excerpt
Few virulence determinants of Helicobacter pylori have been tested in vivo. We conducted this study to establish an animal model for their screening. Six-week-old male Mongolian gerbils were inoculated with wild-type H. pylori (TN2) or its isogenic mutant with deletion of cagE (TN2DeltacagE), total cag pathogenicity island (TN2DeltacagPAI), HP0499 (TN2DeltaHP499), or HP0638 (TN2DeltaHP638) (n=5 each). The animals...
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