Characterization of two hybrid C4 allotypes (C4A*12 and C4B*3) by electrophoretic, serological and restriction fragment length polymorphism analyses.

doi:10.1111/j.1399-0039.1990.tb01760.x

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Article

Characterization of two hybrid C4 allotypes (C4A12 and C4B3) by electrophoretic, serological and restriction fragment length polymorphism analyses.

Tissue antigens - 1 Feb 1990

McLean R H, Bias W B, Giles C, Yu C Y, Campbell R D

Abstract excerpt

Informative pedigree analysis of two rare C4 allotypes is reported. One proband was C4A deficient as a consequence of having one haplotype with a deleted C4A gene, and the second haplotype with two C4B genes--one encoding the common C4B*1 and one encoding a unique hybrid gene product C4B*3. C4B*3 had approximately normal C4B hemolytic activity, a single alpha-chain of MR 94,000 by SDS-PAGE but was positive for...

Topics

Adolescent
Child
Chromosome Mapping
Complement C4a
Complement C4b
Electrophoresis, Polyacrylamide Gel
Epitopes
Female
Gene Conversion
Haplotypes
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunoglobulin Allotypes

Male

Pedigree

Phenotype

Polymorphism, Restriction Fragment Length

Precipitin Tests

Source

Open in PubMed

Identifiers

PMID: 1693017
DOI: 10.1111/j.1399-0039.1990.tb01760.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1693017-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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