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Article

Characterization of two hybrid C4 allotypes (C4A12 and C4B3) by electrophoretic, serological and restriction fragment length polymorphism analyses.

Tissue antigens - 1 Feb 1990

McLean R H, Bias W B, Giles C, Yu C Y, Campbell R D

Abstract excerpt

Informative pedigree analysis of two rare C4 allotypes is reported. One proband was C4A deficient as a consequence of having one haplotype with a deleted C4A gene, and the second haplotype with two C4B genes--one encoding the common C4B*1 and one encoding a unique hybrid gene product C4B*3. C4B*3 had approximately normal C4B hemolytic activity, a single alpha-chain of MR 94,000 by SDS-PAGE but was positive for...

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PMID: 1693017
DOI: 10.1111/j.1399-0039.1990.tb01760.x

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