Article
A point mutation uncouples RNA 3'-end formation and termination during ribosomal gene transcription in Xenopus laevis.
Genes & development - 1 Feb 1990
Labhart P, Reeder R H
Abstract excerpt
Two sites, T2 and T3, in the ribosomal gene spacer of Xenopus laevis both direct RNA 3'-end formation 15 bp upstream of the conserved box sequence GACTTGC. Site T2, which defines the 3' end of the 40S precursor, does not terminate transcription whereas site T3 at the 3' end of the spacer does. Here we show that T2 can be converted into a T3-like site with termination activity by a single point mutation 2 bp...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.