Article
Dynamics of yeast prion aggregates in single living cells.
Genes to cells : devoted to molecular & cellular mechanisms - 1 Sept 2006
Kawai-Noma Shigeko, Ayano Satoru, Pack Chan-Gi, Kinjo Masataka, Yoshida Masasuke, Yasuda Kenji, Taguchi Hideki
Abstract excerpt
Prions are propagating proteins that are ordered protein aggregates, in which the phenotypic trait is retained in the altered protein conformers. To understand the dynamics of the prion aggregates in living cells, we directly monitored the fate of the aggregates using an on-chip single-cell cultivation system as well as fluorescence correlation spectroscopy (FCS). Single-cell imaging revealed that the visible...
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