Article
H-NS controls metabolism and stress tolerance in Escherichia coli O157:H7 that influence mouse passage.
BMC microbiology - 15 Aug 2006
Erol Irfan, Jeong Kwang-Cheol, Baumler David J, Vykhodets Boris, Choi Sang Ho, Kaspar Charles W
Abstract excerpt
BACKGROUND: H-NS is a DNA-binding protein with central roles in gene regulation and nucleoid structuring in Escherichia coli. There are over 60 genes that are influenced by H-NS many of which are involved in metabolism. To determine the significance of H-NS-regulated genes in metabolism and stress tolerance, an hns mutant of E. coli O157:H7 was generated (hns::nptI, FRIK47001P) and its growth, metabolism, and...
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