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Article

New strategy for comprehensive analysis of gene functions in embryonic stem cells.

Ernst Schering Research Foundation workshop - 1 Jan 2006

Takeda J, Horie K, Yusa K

Abstract excerpt

At present, the limitation of Phenotype-based genetic screening in embryonic stem cells (ESCs) is the diploid nature of the genome. Since it is known that cells deficient in the Bloom's syndrome gene (Blm) show an increased rate of homologous recombination, we have developed a new system to conditionally regulate the Blm allele for introduction of bi-allelic mutations across the genome. Transient deficiency of...

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Identifiers

PMID: 16903413
DOI: 10.1007/3-540-31437-7_2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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