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Effect of Dietary Apigenin on Colonic Ornithine Decarboxylase Activity, Aberrant Crypt Foci Formation, and Tumorigenesis in Different Experimental Models

1 Jul 2006

Abstract excerpt

The efficacy of dietary apigenin, a dietary flavonoid, in colon cancer prevention was investigated by evaluating the inhibition of the ornithine decarboxylase (ODC) activity and the formation of aberrant crypt foci (ACF) and by studying the ability of apigenin to block colon carcinogenesis in two mouse models. First, the activity of ODC was measured in colon cancer cells (Caco-2) and in the colon epithelium of...

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PMID: 16898869
DOI: 10.1207/s15327914nc5402_11

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