Article
The mismatch repair protein Msh6 influences the in vivo AID targeting to the Ig locus.
Immunity - 1 Apr 2006
Li Ziqiang, Zhao Chunfang, Iglesias-Ussel Maria D, Polonskaya Zhanna, Zhuang Min, Yang Guozhe, Luo Zhonghui, Edelmann Winfried, Scharff Matthew D
Abstract excerpt
Somatic hypermutation (SHM) and class switch recombination (CSR) are initiated by activation-induced cytidine deaminase (AID), which preferentially deaminates deoxycytidines at WRC (W = A/T, R = A/G) motifs in vitro. The mechanisms responsible for targeting AID and for organizing the queue of enzymes involved in vivo have been elusive. Here, we examined point mutant knockin Msh6 mice (Msh6(TD/TD)), which lack the...
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