Article
Protective effect of apolipoprotein E2 on coronary artery disease in African Americans is mediated through lipoprotein cholesterol.
Journal of lipid research - 1 Nov 2006
Anuurad Erdembileg, Rubin Jill, Lu Guijing, Pearson Thomas A, Holleran Steve, Ramakrishnan Rajasekhar, Berglund Lars
Abstract excerpt
We studied the relationship of apolipoprotein E (apoE) isoforms and coronary artery disease (CAD) in 224 African Americans and 326 Caucasians undergoing diagnostic coronary angiography. The presence of CAD was defined as >50% stenosis in at least one artery. ApoE allele frequencies were 0.12, 0.62, and 0.26 for epsilon 2, epsilon 3, and epsilon 4, respectively, in African Americans and 0.08, 0.78, and 0.14 for...
Topics
- Black or African American
- Alleles
- Apolipoprotein E2
- Black People
- Cholesterol
- Cholesterol, LDL
- Coronary Angiography
- Coronary Artery Disease
- Female
- Gene Frequency
- Humans
- Lipids
- Lipoproteins
- Male