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Article

Antileukemic Activity of Shepherdin and Molecular Diversity of Hsp90 Inhibitors

2 Aug 2006

Abstract excerpt

BACKGROUND: Heat shock protein 90 (Hsp90) is a molecular chaperone that is involved in signaling pathways for cell proliferation, survival, and cellular adaptation. Inhibitors of Hsp90 are being examined as cancer therapeutic agents, but the molecular mechanism of their anticancer activity is still unclear. We investigated Hsp90 as a therapeutic target for acute myeloid leukemia (AML) by use of the Hsp90...

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PMID: 16882944
DOI: 10.1093/jnci/djj300

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