Article
Modulation and compensation of the mRNA expression of energy related transporters in the brain of glucose transporter 1-deficient mice.
Biological & pharmaceutical bulletin - 1 Aug 2006
Ohtsuki Sumio, Kikkawa Tazuru, Hori Satoko, Terasaki Tetsuya
Abstract excerpt
Facilitative glucose transporter 1 (GLUT1) is the molecule responsible for the entry of glucose into the brain, and its mutation is known as GLUT1 deficiency syndrome (GLUT1DS) in humans. To clarify the effect of GLUT1 gene deficiency, we have produced GLUT1-deficient mice, and investigated the developmental expression of GLUT1, monocarboxylate transporter 1 (MCT1) and MCT2 in the brains of these mice. Since the...
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