Article
Baseline gene expression predicts sensitivity to gefitinib in non-small cell lung cancer cell lines.
Molecular cancer research : MCR - 1 Aug 2006
Coldren Christopher D, Helfrich Barbara A, Witta Samir E, Sugita Michio, Lapadat Razvan, Zeng Chan, Barón Anna, Franklin Wilbur A, Hirsch Fred R, Geraci Mark W, Bunn Paul A
Abstract excerpt
Tyrosine kinase inhibitors (TKI) of the epidermal growth factor receptor (EGFR) produce objective responses in a minority of patients with advanced-stage non-small cell lung cancer (NSCLC), and about half of all treated patients progress within 6 weeks of instituting therapy. Because the target of these agents is known, it should be possible to develop biological predictors of response, but EGFR protein levels...
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