Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of Biomarkers in Human Head and Neck Tumor Cell Lines That Predict For <i>In Vitro</i> Sensitivity to Gefitinib

8 May 2009

Abstract excerpt

Potential biomarkers were identified for in vitro sensitivity to the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor gefitinib in head and neck cancer. Gefitinib sensitivity was determined in cell lines, followed by transcript profiling coupled with a novel pathway analysis approach. Eleven cell lines were highly sensitive to gefitinib (inhibitor concentration required to give 50% growth...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related gene regulation
Share to Colorectal Cancer Treatments and Studies
Share to Lung Cancer Treatments and Mutations

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20443891
DOI: 10.1111/j.1752-8062.2009.00099.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of Biomarkers in Human Head and Neck Tumor Cell Lines That Predict For <i>In Vitro</i> Sensitivity to GefitinibPMID 20443891Read ↗

Randomized phase II study of preoperative Afatinib in untreated head and neck cancers: predictive and pharmacodynamic biomarkers of efficacySemantic proximity Read ↗

Biomarker identification for statin sensitivity of cancer cell linesSemantic proximity Read ↗

Molecular phenotype predicts sensitivity of squamous cell carcinoma of the head and neck to epidermal growth factor receptor inhibition.Semantic proximity Read ↗

Candidate genes for sensitivity and resistance of human glioblastoma multiforme cell lines to erlotinibSemantic proximity Read ↗

Biomarkers predicting chemotherapy response in head and neck squamous cell carcinoma: a review.Semantic proximity Read ↗

A transcriptomic map of EGFR-induced epithelial-to-mesenchymal transition identifies prognostic and therapeutic targets for head and neck cancerSemantic proximity Read ↗

Exploring biomarkers in head and neck cancer.Semantic proximity Read ↗

Exploiting high-throughput cell line drug screening studies to identify candidate therapeutic agents in head and neck cancer.Semantic proximity Read ↗

A chemical genetic screen identifies Aurora kinases as a therapeutic target in EGFR T790M negative, gefitinib-resistant head and neck squamous cell carcinoma (HNSCC).Semantic proximity Read ↗

Is biomarker research advancing in the era of personalized medicine for head and neck cancer?Semantic proximity Read ↗

Validation of gefitinib effectiveness in a broad panel of head and neck squamous carcinoma cells.Semantic proximity Read ↗

Preclinical activity of gefitinib in non-keratinizing nasopharyngeal carcinoma cell lines and biomarkers of responseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.