Endotoxin-Induced Silencing of Mesoderm Induction and Functional Differentiation: Role of HMGB1 in Pluripotency and Infection

Abstract excerpt

OBJECTIVES: Mechanisms underpinning Gram-negative bacterial vaginosis-induced birth anomalies are obscure. Ethical issues limit such studies on peri-implantation-stage human embryos. Here we have used embryoid bodies (EBs) as an in vitro model to examine the effect of Gram-negative bacterial endotoxins/lipopolysaccharides (LPS) on the faithful induction of germ lineages during embryogenesis. The role of...

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