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Article

Cisplatin Induces Apoptosis in Mouse Neonatal Testes Organ Culture

1 Nov 2022

Abstract excerpt

Chemotherapy is used for childhood cancer but may lead to infertility in patients. Spermatogonia stem cells are present in the testes of prepubertal boys, although they do not produce sperm at this age. Herein, we evaluated the toxicity of cisplatin, a known medicine for cancer treatment, in neonatal mouse testes using in vitro organ culture. Mouse testicular fragments (MTFs) derived from 5.5-d postpartum mouse...

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PMID: 36362147
DOI: 10.3390/ijms232113360

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