Article
Aberrant collagenase expression in chronic idiopathic myelofibrosis is related to the stage of disease but not to the JAK2 mutation status.
The American journal of pathology - 1 Aug 2006
Bock Oliver, Neuse Johanne, Hussein Kais, Brakensiek Kai, Buesche Guntram, Buhr Thomas, Wiese Birgitt, Kreipe Hans
Abstract excerpt
Bone marrow fibrosis in chronic idiopathic myelofibrosis (cIMF) most likely represents an imbalance between synthesis and turnover of collagen fibers. Because the JAK-STAT signaling pathway is involved in the regulation of genes encoding matrix metalloproteinases (MMPs), we examined the expression of MMPs, their tissue inhibitors (TIMPs), and collagen types in relation to the JAK2 status (V617F mutation versus...
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