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Article

Study design options in evaluating gene-environment interactions: practical considerations for a planned case-control study of pediatric leukemia.

Pediatric blood & cancer - 1 Apr 2007

Goodman Michael, Dana Flanders W

Abstract excerpt

BACKGROUND: We compare methodological approaches for evaluating gene-environment interaction using a planned study of pediatric leukemia as a practical example. We considered three design options: a full case-control study (Option I), a case-only study (Option II), and a partial case-control study (Option III), in which information on controls is limited to environmental exposure only. PROCEDURE: For each design...

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Identifiers

PMID: 16874764
DOI: 10.1002/pbc.20933

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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