Article
Maltodextrin utilization plays a key role in the ability of group A Streptococcus to colonize the oropharynx.
Infection and immunity - 1 Aug 2006
Shelburne Samuel A, Sumby Paul, Sitkiewicz Izabela, Okorafor Nnaja, Granville Chanel, Patel Payal, Voyich Jovanka, Hull Richard, DeLeo Frank R, Musser James M
Abstract excerpt
Analysis of multiple group A Streptococcus (GAS) genomes shows that genes encoding proteins involved in carbohydrate utilization comprise some 15% of the core GAS genome. Yet there is a limited understanding of how carbohydrate utilization contributes to GAS pathogenesis. Previous genome-wide GAS studies led us to a focused investigation of MalE, a putative maltodextrin-binding protein. Analysis of 28 strains of...
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