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Article

CART variance stabilization and regularization for high-throughput genomic data.

Bioinformatics (Oxford, England) - 15 Sept 2006

Papana Ariadni, Ishwaran Hemant

Abstract excerpt

MOTIVATION: mRNA expression data obtained from high-throughput DNA microarrays exhibit strong departures from homogeneity of variances. Often a complex relationship between mean expression value and variance is seen. Variance stabilization of such data is crucial for many types of statistical analyses, while regularization of variances (pooling of information) can greatly improve overall accuracy of test...

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PMID: 16844707
DOI: 10.1093/bioinformatics/btl384

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