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Article

An empirical bayes adjustment to increase the sensitivity of detecting differentially expressed genes in microarray experiments.

Bioinformatics (Oxford, England) - 22 Jan 2004

Datta Susmita, Satten Glen A, Benos Dale J, Xia Jiazeng, Heslin Martin J, Datta Somnath

Abstract excerpt

MOTIVATION: Detection of differentially expressed genes is one of the major goals of microarray experiments. Pairwise comparison for each gene is not appropriate without controlling the overall (experimentwise) type 1 error rate. Dudoit et al. have advocated use of permutation-based step-down P-value adjustments to correct the observed significance levels for the individual (i.e. for each gene) two sample...

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PMID: 14734315
DOI: 10.1093/bioinformatics/btg396

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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