Article
PhenoChipping of psychotic disorders: a novel approach for deconstructing and quantitating psychiatric phenotypes.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Sept 2006
Niculescu Alexander B, Lulow Len L, Ogden Corey A, Le-Niculescu Helen, Salomon Daniel R, Schork Nicholas J, Caligiuri Michael P, Lohr James B
Abstract excerpt
Psychiatric phenotypes as currently defined are primarily the result of clinical consensus criteria rather than empirical research. We propose, and present initial proof of principle for, a novel approach to characterizing psychiatric phenotypes. We have termed our approach PhenoChipping, by analogy with, and borrowing paradigms and tools from, gene expression microarray studies (GeneChipping). A massive parallel...
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