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Article

Immunoglobulin class and subclass deficiencies prior to Epstein-Barr virus infection in males with X-linked lymphoproliferative disease.

American journal of medical genetics - 1 Sept 1991

Grierson H L, Skare J, Hawk J, Pauza M, Purtilo D T

Abstract excerpt

Patients with X-linked lymphoproliferative (XLP) disease are characterized by extreme vulnerability to Epstein-Barr virus (EBV). Following infection with EBV, affected males develop fatal infectious mononucleosis (IM), hypogammaglobulinemia (H), or non-Hodgkin's lymphoma (NHL). In addition, hyper IgM, red cell aplasia, necrotizing lymphoid vasculitis (NLV), and aplastic anemia occur rarely. The recent use of DNA...

Topics

Genetic Linkage
Genetic Predisposition to Disease
Herpesviridae Infections
Herpesvirus 4, Human
Humans
Immunoglobulins
Immunologic Deficiency Syndromes
Lymphoproliferative Disorders
Male
Polymerase Chain Reaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Restriction Fragment Length

X Chromosome

Source

Identifiers

PMID: 1683154
DOI: 10.1002/ajmg.1320400309

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1683154-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Immunoglobulin class and subclass deficiencies prior to Epstein-Barr virus infection in males with X-linked lymphoproliferative disease.PMID 1683154Read ↗

Evaluation of families wherein a single male manifests a phenotype of X-linked lymphoproliferative disease (XLP).Semantic proximity Read ↗

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[X-chromosome recessive lymphoproliferative disease (XLP): molecular genetic studies].Semantic proximity Read ↗

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CD40 ligand expression deficiency in a female carrier of the X-linked hyper-IgM syndrome as a result of X chromosome lyonization.Semantic proximity Read ↗

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