Article
X-linked lymphoproliferative disease: twenty-five years after the discovery.
Pediatric research - 1 Oct 1995
Seemayer T A, Gross T G, Egeler R M, Pirruccello S J, Davis J R, Kelly C M, Okano M, Lanyi A, Sumegi J
Abstract excerpt
The X-linked lymphoproliferative disease (XLP), one of six described X-linked immunodeficiencies, stems from a mutation at Xq25 which renders males impotent to mount an effective immune response to the ubiquitous EBV. Purtilo, who first observed this disease in 1969, established a Registry in 1980 to serve as a worldwide resource for the diagnosis, treatment, and research of this condition. Since Purtilo's death...
Topics
- Child
- Chromosome Mapping
- Female
- Genetic Carrier Screening
- Genetic Linkage
- Herpesviridae Infections
- Herpesvirus 4, Human
- History, 20th Century
- Humans
- Lymphoproliferative Disorders
- Male