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Article

Can the state of cancer chemotherapy resistance be reverted by epigenetic therapy?

1 Jan 2006

Abstract excerpt

BACKGROUND: Transcriptome analysis shows that the chemotherapy innate resistance state of tumors is characterized by: poorly dividing tumor cells; an increased DNA repair; an increased drug efflux potential by ABC-transporters; and a dysfunctional ECM. Because chemotherapy resistance involves multiple genes, epigenetic-mediated changes could be the main force responsible of this phenotype. Our hypothesis deals...

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PMID: 16831224
DOI: 10.1186/1476-4598-5-27

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