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Article

MDR1, chemotherapy and chromatin remodeling.

Cancer biology & therapy - 1 Sept 2004

Baker Emma K, El-Osta Assam

Abstract excerpt

The development of multidrug resistance (MDR) in cancer can severely impede the efficacy of chemotherapy treatment. P-glycoprotein (Pgp) overexpression, encoded by the MDR1 gene, is a well-established mediator of MDR. MDR1 expression is rapidly upregulated by chemotherapeutic drugs and a number of other exogenous stimuli, however the mechanisms underlying its transcriptional regulation remain unclear. In recent...

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Share to Antineoplastic Agents
Share to ATP Binding Cassette Transporter, Subfamily B, Member 1
Share to Chromatin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Drug Resistance, Multiple

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Identifiers

PMID: 15326379
DOI: 10.4161/cbt.3.9.1101

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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