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Article

Sebaceous neoplasms and the immunoprofile of mismatch-repair proteins as a screening target for syndromic cases.

Pathology, research and practice - 1 Jan 2015

Boennelycke Marie, Thomsen Birthe M, Holck Susanne

Abstract excerpt

INTRODUCTION: Muir-Torre syndrome (MTS), a subset of Lynch syndrome, is characterized by concurrent or sequential development of sebaceous neoplasms, and internal malignancies, specifically colorectal carcinoma (CRC), and can be related to mismatch-repair (MMR)-protein deficiency. In CRC context, p16-negativity in MLH1-deficient cases may denote methylation rather than mutation. The prime aim of this study was to...

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Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25457183
DOI: 10.1016/j.prp.2014.10.002

Genes

MLH1
MSH6
PMS2
MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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