Article
Mutation-induced metabolite pool alterations in Corynebacterium glutamicum: towards the identification of nitrogen control signals.
Journal of biotechnology - 1 Dec 2006
Müller Tim, Strösser Julia, Buchinger Sebastian, Nolden Lars, Wirtz Astrid, Krämer Reinhard, Burkovski Andreas
Abstract excerpt
The influence of glutamate dehydrogenase activity on nitrogen regulation in Corynebacterium glutamicum was investigated. As shown by RNA hybridization experiments deletion of the gdh gene results in a rearrangement of nitrogen metabolism. Even when sufficiently supplied with nitrogen sources, a gdh deletion strain showed the typical nitrogen starvation response of C. glutamicum. These changes in transcription...
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