Article
Paired box genes, PAX-2 and PAX-8, are not frequently mutated in Wilms tumor.
Mutation research - 10 Oct 2006
Tamimi Yahya, Dietrich Kevin, Stone Kathryn, Grundy Paul
Abstract excerpt
To determine whether PAX-2 and PAX-8 are involved in Wilms tumor (WT) pathogenesis, we sought mutations in these two genes in 99 Wilms tumors of favorable histology. We screened the entire protein coding sequences as well as the intronic regions adjacent to exons, using denaturing HPLC followed by sequencing of samples displaying abnormal chromatograms. In PAX-2, a silent polymorphism was found within exon 2 and...
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