Article
Hormone-replacement therapy influences gene expression profiles and is associated with breast-cancer prognosis: a cohort study
30 Jun 2006
Abstract excerpt
BACKGROUND: Postmenopausal hormone-replacement therapy (HRT) increases breast-cancer risk. The influence of HRT on the biology of the primary tumor, however, is not well understood. METHODS: We obtained breast-cancer gene expression profiles using Affymetrix human genome U133A arrays. We examined the relationship between HRT-regulated gene profiles, tumor characteristics, and recurrence-free survival in 72...
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