Fragile X-linked mental retardation and the difficulties of reverse genetics.

doi:10.1002/bies.950130508

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Article

Fragile X-linked mental retardation and the difficulties of reverse genetics.

BioEssays : news and reviews in molecular, cellular and developmental biology - 1 May 1991

Jordan B R

Abstract excerpt

Fragile X-linked mental retardation is an enigmatic inheritable syndrome in which severe mental retardation, a cytogenetically detectable fragile site at Xq27.3 (FraX) and a number of dysmorphic features are associated. Genetic analysis shows that the mode of inheritance is more complex than a straightforward X-linked recessive trait and probably involves a two-step process for which several models have been...

Topics

Animals
Cells, Cultured
Chromosome Mapping
Cricetinae
Crossing Over, Genetic
DNA
DNA Mutational Analysis
Female
Folic Acid
Fragile X Syndrome
Genes, Recessive
Genetic Markers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Vectors

Heterozygote

Humans

Hybrid Cells

Intellectual Disability

Male

Source

Open in PubMed

Identifiers

PMID: 1679986
DOI: 10.1002/bies.950130508

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1679986-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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