The coordinated evolution of yeast proteins is constrained by functional modularity.

doi:10.1016/j.tig.2006.06.008

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Article

The coordinated evolution of yeast proteins is constrained by functional modularity.

Trends in genetics : TIG - 1 Aug 2006

Chen Yiwen, Dokholyan Nikolay V

Abstract excerpt

Functional modularity is a key attribute of cellular systems and has important roles in evolution. However, the extent to which functional modularity affects protein evolution is largely unknown. Here, we analyzed the evolution of both sequence and expression level of proteins in the yeast Saccha...

Topics

Evolution, Molecular
Gene Expression
Mutation
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
Sequence Analysis, Protein

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