Article
Changes in primary DNA sequence complexity influence the phenotypic consequences of mutations in human gene regulatory regions.
Human genetics - 1 Oct 2000
Krawczak M, Chuzhanova N A, Stenson P D, Johansen B N, Ball E V, Cooper D N
Abstract excerpt
No general rules have been proposed to account for the functional consequences of gene regulatory mutations. In a first attempt to establish the nature of such rules, an analysis was performed of the DNA sequence context of 153 different single base-pair substitutions in the regulatory regions of...
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