Article
Evaluation of the association between OPA1 polymorphisms and primary open-angle glaucoma in Barbados families.
Molecular vision - 12 Jun 2006
Yao Wenliang, Jiao Xiaodong, Hejtmancik J Fielding, Leske M Cristina, Hennis Anselm, Nemesure Barbara
Abstract excerpt
PURPOSE: To investigate whether single nucleotide polymorphisms (SNPs) in the OPA1 gene are associated with two primary open-angle glaucoma (POAG) subgroups: those with elevated intraocular pressure (POAG/IOP) and those with normal tension glaucoma (NTG) in the African-Caribbean population of Barbados, West Indies. METHODS: SNPs at intervening sequence (IVS) 8, +4, and +32 of the OPA1 gene were directly sequenced...
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