Using cDNA microarrays to identify human CD19(+) B cell gene products (ESTs) originated from systemic lupus erythematosus susceptibility loci.

doi:10.1016/j.autrev.2005.11.003

Article

Using cDNA microarrays to identify human CD19(+) B cell gene products (ESTs) originated from systemic lupus erythematosus susceptibility loci.

Autoimmunity reviews - 1 May 2006

Trevisan Glauce L, Rassi Diane M, Baião Ana M T, Sandrin-Garcia Paula, Mello Stephano S, Tamia-Ferreira Márcia C, Junta Cristina M, Fachin Ana L, Marques Márcia M C, Sakamoto-Hojo Elza T, Donadi Eduardo A, Passos Geraldo A S

Abstract excerpt

Systemic lupus erythematosus (SLE) is a prototype of autoimmune disease which arises from interactions between susceptibility genes and environmental factors. Despite the heterogeneous manifestations in this disease, all SLE patients present plasma autoantibodies recognizing nuclear components. Thus, auto reactive B cells represent key effectors to be investigated. Human linkage analysis is providing the...

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